Development and application of an experimental system to analyze centromere dysfunctions that promote cancer

Professor Tatsuro Fukagawa, Department of Molecular Genetics, National Institute of Genetics
(FY2010-2012)

This study aims to develop an experimental system that efficiently produces cells with centromere dysfunction for the purpose of understanding the relationship between centromere dysfunction and chromosomal stability.

FY2010 results

1. As per this year's goals, we were able to identify several novel proteins.
2. We produced some initially unplanned products (nine centromere protein-related antibodies, on sale August 18, 2010 from MBL) and trial products, with results as a whole exceeding objectives.
3. We published nine papers in March 2010, and the research is proceeding smoothly.